Beneficial Effects of Total Phenylethanoid Glycoside Fraction Isolated from Cistanche deserticola on Bone Microstructure in Ovariectomized Rats

Figure 9

Hypothesized molecular mechanism: CDP could prevent bone loss on the OVX rat through RANKL/RANK/TRAF6-induced inactivation of NF-κB and activation of PI3K/AKT pathways as well as c-Fos stimulation and NFAT2 suppression, which are evidenced by the downregulation of the expression levels of TRAF6, RANKL, RANK, NF-κBIA, and NFAT2, whereas c-Fos, AKT, and PI3K were significantly upregulated by CDP treatment as compared to the control group.