Sesamin Enhances Nrf2-Mediated Protective Defense against Oxidative Stress and Inflammation in Colitis via AKT and ERK Activation

Figure 6

SSM reactivated Nrf2 signaling via activating ERK and AKT against DSS-induced colitis. (a) The effect of SSM on the ERK, AKT, P38, PKC, and Keap1 in the colon of mice with colitis was detected using western blot. Quantitative data were obtained from the densitometric quantification of immunoblots using ImageJ software. (b) The protein expressions of Nrf2 and its target genes in the colon of mice with colitis were analyzed by western blot. Quantitative data were obtained from the densitometric quantification of immunoblots by using ImageJ software. Data were expressed as the (). and versus the control. ^#, ^##, and ^### versus the 3% DSS treatment group.

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