Oxidative Medicine and Cellular Longevity / 2019 / Article / Fig 3

Research Article

p53-Mediated PI3K/AKT/mTOR Pathway Played a Role in PtoxDpt-Induced EMT Inhibition in Liver Cancer Cell Lines

Figure 3

The immigration and invasion inhibition of PtoxDpt against hepatocellular carcinoma cells. (a) The migratory inhibition of PtoxDpt against HCCLM3 cells. (b) Quantitative analysis from (a): the invasive cells were stained with crystal violet. The results were expressed as invasive cell numbers per field of view ( SD, ). (c) The wounded HCCLM3 cells were treated with 0.0, 0.78, and 1.56 μM PtoxDpt for 24 h. (d) Quantitative analysis of the width of gaps. (e) Gelatin zymography (A) and Western blotting (B) analyses of matrix metalloprotease inhibition; the condition was as indicated in the experimental section. compared with the DMSO-treated group.

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