Interactions between Cytosolic Phospholipase A2 Activation and Mitochondrial Reactive Oxygen Species Production in the Development of Ventilator-Induced Diaphragm Dysfunction

<div>Hypoxia induced cPLA2 activation and mitochondrial ROS generation <i>in vitro</i>. (a) Western blots for HIF-1<i>α</i> expressions in C2C12 cells; (b) changes of cPLA2 activities in C2C12 cells underwent indicated time of hypoxia; (c) effects of AACOCF3 and SS31 on cPLA2 activities in C2C12 cells after 12 hours of hypoxia; (d) MitoSOX assay for the detection of mitochondrial ROS generation in C2C12 cells; (e) fluorescence intensities of MitoSOX; (f) effects of AACOCF3 and SS31 on calpain activities in C2C12 cells after 12 hours of hypoxia. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Interactions between Cytosolic Phospholipase A2 Activation and Mitochondrial Reactive Oxygen Species Production in the Development of Ventilator-Induced Diaphragm Dysfunction 

Figure 5 | Interactions between Cytosolic Phospholipase A2 Activation and Mitochondrial Reactive Oxygen Species Production in the Development of Ventilator-Induced Diaphragm Dysfunction 