Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease

Figure 7

The thioredoxin system and its relationship with glucose metabolism in the pentose phosphate cycle. The pentose phosphate cycle generates reducing equivalents which are transferred along a series of cycling redox reactions. Induction of Trx and Trx reductase by SFN enables glucose to be metabolised as an alternative to the synthesis of superoxide radical to alleviate much of the metabolic stress associated with T2DM (a figure adapted from Holmgren and Lu [169]).