Luteolin Attenuates Cardiac Ischemia/Reperfusion Injury in Diabetic Rats by Modulating Nrf2 Antioxidative Function

Table 1

Effect of luteolin on left ventricular hemodynamic parameters in diabetic rat hearts exposed to ischemia/reperfusion.

Variable	Baseline	Reperfusion (min)
		30	60	120
RPP (% of baseline)
ND	100 ( beats/min)
D	100 ( beats/min)^+			^++
D+Lut	100 ( beats/min)
D+L-NAME+Lut	100 ( beats/min)^#		^##	^##
D+Brusatol+Lut	100 ( beats/min)^#		^##	^##
LVEDP (mmHg)
ND
D				^++
D+Lut
D+L-NAME+Lut		^#	^#	^##
D+Brusatol+Lut		^#	^#	^##

Data are , rats/group. ND: nondiabetic rats; D: STZ diabetic rats; D+Lut: STZ diabetic rats treated with luteolin (100 mg/kg/d); D+L-NAME+Lut: diabetic rats treated with the NOS inhibitor L-NAME (25 mg/kg/d) and luteolin; D+Brusatol+Lut: diabetic rats treated with the Nrf2 inhibitor brusatol (0.4 mg/kg/2d) and luteolin. Six weeks after STZ injection, L-NAME and luteolin were administered intragastrically for 2 weeks. Hearts were isolated and subjected to global ischemia for 30 min and reperfusion for 120 min. and versus ND; and versus D; versus D+Lut.