The Preventive Effects and the Mechanisms of Action of Navel Orange Peel Hydroethanolic Extract, Naringin, and Naringenin in N-Acetyl-p-aminophenol-Induced Liver Injury in Wistar Rats

Figure 6

Immunohistochemically stained liver sections for caspase-3 expression detection. (a) Negative or very weak immunohistochemical reaction in normal control. (b) Strong immunohistochemical reaction marked by a dark brown colour in hepatocytes in the liver of APAP-administered rats. (c-e) Low expression of caspase-3 in APAP-administered rats treated with the navel orange peel extract (c) and naringin (d) and moderate immunohistochemical reaction in APAP-administered rats treated with naringenin (e) (×200).

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