Upregulation of UCP2 Expression Protects against LPS-Induced Oxidative Stress and Apoptosis in Cardiomyocytes
The effect of UCP2 knockdown on mitochondrial function and morphology with LPS treatment. Cardiomyocytes were transduced with Ad-shRNA-NC or Ad-shRNA-UCP2 adenovirus followed by treatment with or without 25 μM LPS. (a) Cardiomyocytes were stained with JC-1 to determine the mitochondrial membrane potential (ΔΨm) by flow cytometry. (b) The mitochondrial ultrastructure was imaged using a transmission electron microscope. Data were collected from three individual experiments and presented as the . vs. shRNA-NC, vs. shRNA-NC+LPS.
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