Morinda citrifolia and Its Active Principle Scopoletin Mitigate Protein Aggregation and Neuronal Apoptosis through Augmenting the DJ-1/Nrf2/ARE Signaling Pathway

Figure 1

(a) Photographic representation of the TH-positive neurons in the striatum and in SNPc. (b) Quantification of relative intensity of TH staining in the striatum using the densitometry protocol through ImageJ was performed to substantiate the potentials of salvaging activity of MCE. (c) Impact of MCE on rotenone-induced oxidative stress: values are expressed as for six animals in each group. (d) Immunoblot analysis of iNOS and nitrotyrosine (i.e. α-synuclein) and representative densitometry quantification. Statistical significance () was calculated by Student-Newman-Keuls and least significant difference post hoc test, where represents control vs. other groups, represents rotenone vs. LD, MCE.

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