New Insights into Chronological Mobility of Retrotransposons In Vivo
Chronological expression of P16INK4a in different organs. (a) RT-qPCR, of P16INK4a mRNA, in different mouse organs. Significant upregulation was observed in the mouse brain, kidney, and heart. Significant downregulation was observed in testes. No significant changes were observed in the liver or lungs (b–f): P16INK4a protein expression at 1 month (Y), 12 months (M), and 24 months (O) (b) in the brain showed upregulation at M and O compared to Y, (c) in the kidney showed upregulation at M and O compared to Y, (d) in the lungs showed upregulation at M and O compared to Y, (e) in the liver showed downregulation in M and O compared to Y, and (f) in the testis showed upregulation in O compared to Y. The histograms below the panels showed the normalized to the corresponding level of the loading control protein, β-tubulin (,, and ).
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