Peroxiredoxin III Protects Tumor Suppressor PTEN from Oxidation by 15-Hydroperoxy-eicosatetraenoic Acid

Figure 7

A schematic model of 15s-HpETE on the redox regulation of the tumor suppressor PTEN by the Trx system and Prx. Trx and Prx III play vital roles in the control of endogenous lipid peroxide-induced redox regulation of PTEN. 15s-HpETE inhibits the Trx redox system by inducing dimerization of Trx, resulting in the delayed reduction of oxidized PTEN and oxidized Prx. Prx III prevents 15s-HpETE-mediated PTEN oxidation by catalyzing the reduction of lipid peroxide. TrxR: thioredoxin reductase; Trx: thioredoxin; Prx: peroxiredoxin.