Leptin and Adiponectin Signaling Pathways Are Involved in the Antiobesity Effects of Peanut Skin Extract
Silence of leptin receptor with siRNA restrains the antiobesity effects of PSE in obese mice. The changes of leptin receptor gene expression in the liver and hypothalamus of normal mice (a) after injection of leptin receptor siRNA, body weight gain (b), organ weight (c), and gene expression of leptin receptor (d) in the hypothalamus of obese mice after injection of siRNA and administration of PSE. Each point in the figure represents the at corresponding time points. Animal numbers of each group are five. #, ##, and ### represent the significant difference comparison with the normal control at ,, and . and indicate the significant difference comparison with the HFD group at and .