Hepatitis C Virus RNA-Dependent RNA Polymerase Is Regulated by Cysteine S-Glutathionylation

Table 2

Variability of amino acid residues of the NS5B protein from HCV genotypes 1-7 at positions, in which the protein of JFH-1 isolate contains cysteine residues.

Gt

Isolate

14

39

89

146

170

223

243

274

279

295

303

316

366

521

1a

H77

C

S

C

C

C

C

C

C

C

C

C

C

C

C

TN

C

S

C

C

C

C

C

C

C

C

C

C

C

C

HCV1

C

S

C

C

C

C

C

C

C

C

C

C

C

C

1b

Con1

C

A

C

C

C

C

C

C

C

C

C

C

C

C

J4

C

A

C

C

C

C

C

C

C

C

C

N

C

C

DH1

C

A

C

C

C

C

C

C

C

C

C

C

C

C

2a

JFH1

C

C

C

C

C

C

C

C

C

C

C

C

C

C

JFH2

C

C

C

C

C

C

C

C

C

C

C

C

C

C

J6

C

C

C

C

C

C

C

C

C

C

C

C

C

C

2b

J8

C

S

C

C

C

C

C

C

C

C

C

C

C

C

3a

S52

C

S

C

C

C

C

C

C

C

C

A

C

C

C

4a

ED43

C

A

C

A

C

C

C

C

C

C

I

C

C

C

5a

SA13

C

S

C

A

C

C

C

C

C

C

C

C

C

C

6a

EUHK2

C

S

C

C

C

C

C

C

C

C

C

C

C

C

7a

QC69

S

S

A

C

C

C

C

V

C

C

A

C

C

C