Simvastatin Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in Nonalcoholic Steatohepatitis Experimental Model

Table 1

Effect of treatment with simvastatin on DNA damage, liver integrity, total cholesterol, and triglyceride serum levels and hepatic lipids in mice livers with NASH induced by a MCD diet.

	CO+V	SIM 4	NASH+V	NASH+SIM 4
DI
AST (U/L)			^#	^#
ALT (U/L)			^#$	^#$
Total Cholesterol (mg/dL)			^#	^#
Triglyceride (mg/dL)			^#	^#
Cholesterol hepatic (mg cholesterol/mg tissue)
Triglyceride hepatic (mg triglyceride/mg tissue)

CO+V: control plus vehicle (); SIM 4: control plus simvastatin 4 mg/kg (); NASH+V: NASH plus vehicle (); NASH+SIM 4: NASH plus simvastatin 4 mg/kg (). The data are expressed as the (S.D); DI: damage index, which can range from 0 (completely undamaged, ) to 400 (with maximum damage ). CO+V versus NASH+V. ^# versus CO+V and SIM 4. ^$ versus NASH+V. versus CO+V and SIM 4.