Research Article

Simvastatin Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in Nonalcoholic Steatohepatitis Experimental Model

Table 1

Effect of treatment with simvastatin on DNA damage, liver integrity, total cholesterol, and triglyceride serum levels and hepatic lipids in mice livers with NASH induced by a MCD diet.


AST (U/L)##
ALT (U/L)#$#$
Total Cholesterol (mg/dL)##
Triglyceride (mg/dL)##
Cholesterol hepatic (mg cholesterol/mg tissue)
Triglyceride hepatic (mg triglyceride/mg tissue)

CO+V: control plus vehicle (); SIM 4: control plus simvastatin 4 mg/kg (); NASH+V: NASH plus vehicle (); NASH+SIM 4: NASH plus simvastatin 4 mg/kg (). The data are expressed as the (S.D); DI: damage index, which can range from 0 (completely undamaged, ) to 400 (with maximum damage ). CO+V versus NASH+V. # versus CO+V and SIM 4. $ versus NASH+V. versus CO+V and SIM 4.