Research Article

Simvastatin Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in Nonalcoholic Steatohepatitis Experimental Model

Table 3

Effect of treatment with simvastatin on lipid peroxidation, SOD, and Gpx activities in mouse livers with NASH induced by a MCD diet.


TBARS (nmoles/mg prot)$
SOD (U/SOD mg prot)
GPx (nmoles/mg prot)#

CO+V: control plus vehicle (); SIM 4: control plus simvastatin 4 mg/kg (); NASH+V: NASH plus vehicle (); NASH+SIM 4: NASH plus simvastatin 4 mg/kg (). versus CO+V, SIM 4, and NASH+V. $ against versus CO+V, SIM 4, and CO+V. # versus CO+V, SIM 4, and NASH+V.