Research Article

The NADPH Oxidase Nox4 Controls Macrophage Polarization in an NFκB-Dependent Manner

Figure 1

Nox4 deficiency favors inflammation in a murine tumor model. (a) Proinflammatory markers including the cytokines IL1β and TNFα and the adhesion molecule ICAM-1 were quantified by RT-qPCR in tumor tissue of WT and Nox4-/- mice. (b) Proinflammatory markers IL1β (ELISA) and TNFα as well as IL10 (CBA: cytometric bead assay) as anti-inflammatory markers were measured in tumor tissue, ; . (c) Single-cell suspension of tumor tissue was analyzed by FACS for Ly6C+ monocytes; , -10.