The Effect of 600 mg Alpha-lipoic Acid Supplementation on Oxidative Stress, Inflammation, and RAGE in Older Adults with Type 2 Diabetes Mellitus

Table 5

Correlation between ALA, HbA1c, RAGE, and oxidative stress markers after six months.

	ALA	HbA1c	RAGE	SOD	GPx	TAS	AOGAP	SOD/GPx	8-ISOP
ALA	1	0.084	-0.100	0.279	0.249	0.038	0.006	-0.180	-0.247
HbA1c		1.000	-0.020	-0.131	-0.041	0.017	0.061	-0.004	0.157
RAGE			1.000	-0.084	-0.302	-0.245	-0.069	0.290	-0.026
SOD				1.000	0.134	0.119	0.165	-0.076	-0.109
GPx					1.000	-0.060	-0.020	-0.828	-0.145
TAS						1.000	0.649	0.137	0.187
AOGAP							1.000	0.047	0.079
SOD/GPx								1.000	0.139
8-ISOP									1.000
ALA		0.402	0.329	0.005	0.012	0.702	0.952	0.077	0.017
HbA1c			0.845	0.194	0.690	0.862	0.546	0.969	0.134
RAGE				0.415	0.003	0.014	0.504	0.005	0.810
SOD					0.186	0.233	0.103	0.457	0.303
GPx						0.546	0.841	0.000	0.170
TAS							0.000	0.177	0.068
AOGAP								0.653	0.453
SOD/GPx									0.200
8-ISOP

ALA: alpha-lipoic acid; HbA1c: glycosylated hemoglobin; RAGE: receptor for advanced glycation end products; SOD: superoxide dismutase; GPx: glutathione peroxidase; TAS: total antioxidant status; AOGAP: antioxidant gap; SOD/GPx: SOD/GPx ratio; 8-ISOP: 8-isoprostane.