Oxidative Medicine and Cellular Longevity / 2019 / Article / Fig 6

Research Article

Inhibition of Mitofusin-2 Promotes Cardiac Fibroblast Activation via the PERK/ATF4 Pathway and Reactive Oxygen Species

Figure 6

Schematic representation of the PERK/ATF4/ROS pathways through which Mfn2 inhibition triggers cardiac fibroblast activation. Upon pathological stimuli, gene silencing of Mfn2 reduced OMM Mfn2 expression, resulting in elevated expression levels of the PERK/ATF4 branch, and the generation of ROS ultimately leading to cardiac fibroblast activation.

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.