Hydrogen Sulfide as a Novel Regulatory Factor in Liver Health and Disease

Table 3

Protective effects of H₂S on NAFLD/NASH.

Experimental models	Effects	Proposed mechanisms	Refs.
NAFLD in vivo (mouse)	NaHS (56 μmol/kg/day) attenuates HFD-induced NAFLD	Activation of liver autophagy via the AMPK-mTOR pathway	[138]
NAFLD in vivo (mouse)	NaHS (50 μmol/kg/day) mitigates HFD-induced NAFLD	Improvement of lipid metabolism and antioxidant potential	[49]
NAFLD in vivo (mouse)	NaHS (14 μmol/kg) attenuates concanavalin A-induced hepatitis	Inhibition of apoptosis and autophagy partly through activation of the PI3K-AKT1 signaling pathway	[139]
NASH in vivo (rat)	NaHS (28 μmol/kg/day) attenuates MCD-induced NASH	Possibly through abating oxidative stress and suppressing inflammation	[22]
NAFLD in vivo (mouse)	SPRC (an H2S donor, 40 mg/kg/day) exerts a novel protective effect on MCD-induced NAFLD	Antioxidative effect through the PI3K/Akt/Nrf2/HO-1 signaling pathway	[50]

AMPK: adenosine monophosphate-activated protein kinase; mTOR: mammalian target of rapamycin; PI3K: phosphatidylinositol 3-kinase; MCD: methionine-choline-deficient; HO-1: heme oxygenase-1.