Research Article

Suppression of Alzheimer’s Disease-Like Pathology Progression by Mitochondria-Targeted Antioxidant SkQ1: A Transcriptome Profiling Study

Table 1

The mitochondrial function-related genes (i.e., associated with relevant GO terms according to DAVID) that change the expression in untreated (control) OXYS rats; the effect of prolonged treatment with SkQ1. Differential expression means a comparison with the control Wistar strain.

ProcessNumber of DEGs in control OXYS ratsPercentage of DEGs removed by SkQ1Gene symbols

BPMitochondrion organization1191Sept4, Mfn1, Spg7, Samm50, Jun, Mtx1, Tomm40, Bnip3, Bcl2l1, Synj2bp, Dap3
Generation of precursor metabolites and energy1191Atp6v0c, Atp5d, Uqcrc1, Pfkl, Hk2, Atp5c1, Hk1, Cyb5b, Cat, Atp5h, Etfb
Oxidation reduction1580Cyb5r3, Me3, Uqcrc1, Cyb5b, Por, Gsr, Ivd, Ndufv1, Akr7a2, Cat, Alkbh3, Acad11, Mecr, Etfb, Prodh
Oxidative phosphorylation580Atp6v0c, Atp5d, Uqcrc1, Atp5c1, Atp5h
Mitochondrial transport4100Mtx1, Tomm40, Bnip3, Bcl2l1
Apoptotic mitochondrial changes3100Jun, Bcl2l1, Dap3

MFCoenzyme binding1090Cyb5r3, Gsr, Acbd3, Me3, Ivd, Ndufv1, Cat, Parp1, Acad11, Por
Nucleotide binding2871Hsp90ab1, Cyb5r3, Sept4, Me3, Fastkd1, Spg7, Abca9, Hk2, Hk1, Acsf2, Gsr, Ivd, Slc22a4, Abcb10, Cat, Actb, Pdk2, Alpk1, Pfkl, Por, Atad1, Acsm3, Trap1, Hyou1, Mfn1, Ndufv1, Acad11, Parp1
Electron carrier activity786Cyb5r3, Gsr, Ivd, Cyb5b, Acad11, Etfb, Por

CCMitochondrion6676Hsp90ab1, Cyb5r3, Atp5d, Spg7, Uqcrc1, Aurkaip1, Nit1, Nit2, Bnip3, Clybl, Acsf2, Gsr, Acbd3, Dnajc15, Mutyh, Dnajc11, Slc25a22, Akr7a2, Exog, Abcb10, Cat, Atp5h, Abce1, Fech, Pisd, Synj2bp, Cyb5b, Mrm1, Por, Trap1, Mfn1, Slc25a34, Atp5c1, Mecr, Prodh, Me3, Atp5sl, Abca9, Samm50, Mtx1, Hk2, Sfxn4, Hk1, Letm2, Wars2, Bcl2l1, Mrpl11, Ivd, Slc25a46, Etfb, Pdk2, Mobp, Tomm40, Atad1, Acsm3, Mrpl22, Adap2, Hmgcs2, Tfrc, Ndufv1, Gls, Bola1, Alkbh3, Acad11, Dap3, Comtd1
Mitochondrial outer membrane11100Cyb5r3, Mfn1, Samm50, Mtx1, Hk2, Hk1, Tomm40, Bnip3, Bcl2l1, Cyb5b, Synj2bp
Mitochondrial inner membrane1580Cyb5r3, Atp5d, Uqcrc1, Samm50, Letm2, Cyb5b, Hmgcs2, Slc25a34, Ndufv1, Dnajc11, Slc25a22, Atp5c1, Slc25a46, Abcb10, Atp5h
Mitochondrial matrix1292Mrpl11, Atp5d, Acsm3, Pdk2, Fech, Hmgcs2, Ivd, Gls, Atp5c1, Wars2, Etfb, Dap3

DEGs that SkQ1 eliminated in OXYS rats. BP: biological process, MF: molecular function, CC: cellular component.