Melatonin Alleviates Radiation-Induced Lung Injury via Regulation of miR-30e/NLRP3 Axis

<div>Representative flow cytometry plots of lung single-cell suspensions from the control, melatonin, and radiation-treated mice. (a) The gating strategy of CD45+ myeloid lung cells for characterization of pulmonary populations, such as infiltrating macrophages (CD11b+CD11c−) and alveolar macrophages (CD11b int CD11c+). Percentages of F4/80+CD206+ AM macrophage subsets (b) and F4/80+CD206+ infiltrating subsets (c) were statistically analyzed. (d) Percentages of CD11b+Ly6G+ neutrophils within CD45+ cells in the lungs were statistically analyzed. 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Mel, melatonin; IM, interstitial macrophage; AM, alveolar macrophage.</div>

Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Melatonin Alleviates Radiation-Induced Lung Injury via Regulation of miR-30e/NLRP3 Axis 