Alpha Lipoic Acid Improves Endothelial Function and Oxidative Stress in Mice Exposed to Chronic Intermittent Hypoxia
Table 2
Fold changes of gene expression in aortic tissue of mice exposed to intermittent hypoxia and treated with ALA compared to control.
Gene symbol
Name of gene
IHRD
IHLA
IALA
Inflammatory cytokines
IL-6
Interleukin 6
4
46
9
TNF
Tumor necrosis factor alpha
1
34
10
MCP-1
Monocyte chemoattractant protein 1
2
1
1
Ifng
Interferon gamma
36
5
2
Adhesion molecules
Icam1
Intracellular adhesion molecule 1
64
2
1
Vcam1
Vascular cell adhesion molecule 1
56
36
16
Antioxidant enzymes
Sod1
Superoxide dismutase 1
2
74
9
Gpx3
Glutathione peroxidase 3
1
89
4
Hmox1
Heme oxygenase 1
−2
−1
−1
Nqo1
NAD(P)H dehydrogenase
3
3
2
ROS-producing enzymes
Nox1
NADPH oxidase 1
43
5
1
Nox4
NADPH oxidase 4
8
4
2
Student’s unpaired -test was performed on values between groups; values are expressed as ( mice) ( versus IARD). Fold regulation represents fold change in a biologically meaningful way.
