Alpha Lipoic Acid Improves Endothelial Function and Oxidative Stress in Mice Exposed to Chronic Intermittent Hypoxia

Table 3

Fold changes of gene expression in aortic tissue of mice exposed to chronic intermittent hypoxia compared to mice treated with alpha lipoic acid.

	Gene symbol	Name of gene	Fold regulation in IHRD vs. IHLA
Inflammatory cytokines	IL-6	Interleukin 6	−7
	TNF	Tumor necrosis factor alpha	−8
	MCP-1	Monocyte chemoattractant protein 1	−34
	Ifng	Interferon gamma	1
Adhesion molecules	Icam1	Intracellular adhesion molecule 1	−1
	Vcam1	Vascular cell adhesion molecule 1	2
Antioxidant enzymes	Sod1	Superoxide dismutase 1	11
	Gpx3	Glutathione peroxidase 3	29
	Hmox1	Heme oxygenase 1	38
	Nqo1	NAD(P)H dehydrogenase	66
ROS-producing enzymes	Nox1	NADPH oxidase 1	−2
	Nox4	NADPH oxidase 4	−2

Student’s unpaired -test was performed on values between groups; values are expressed as (5-6 mice), versus IHRD. Fold regulation represents fold change in a biologically meaningful way.