Weisheng-Tang Ameliorates Acute Ischemic Brain Damage in Mice by Maintaining Blood-Brain Barrier Integrity

Figure 2

Dose-dependent effects of Weisheng-tang on ischemic brain damage. (a) Mice were pretreated via oral administration of 30, 100, or 300 mg/kg of Weisheng-tang ( each) or PBS (control group, ) once daily for 4 days prior to ischemic insult as well as 1 h prior to the procedure. (b) Representative photographs of coronal brain sections stained with TTC. (c, d) Quantification of direct infarct volume (c) and edema (d) 24 h postischemia. vs. control group. (e–f) Neurological score (e) and wire-grip (f) results were evaluated to assess recovery of neurologic deficit and vestibular motor function after ischemic brain injury. vs. control group. TTC: 2,3,5-triphenyltetrazolium chloride.

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