Oxidative Medicine and Cellular Longevity / 2019 / Article / Tab 1

Review Article

The Naked Mole Rat: A Unique Example of Positive Oxidative Stress

Table 1

Potential positive effects of ROS in naked mole rats.

Type of ROSGene/mechanismsNaked mole ratRef.

Cellular homeostasisH2O2 [75]Nrf2Fibroblasts: Nrf2 ↗
Liver: Nrf2 ↗
H2O2 [77]p53Fibroblasts: p53 ↗
Liver: p53 ↗
[80, 83]
H2O2 [84]PTEN17 copies of PTEN pseudogenes[85]

Immune systemO2-/H2O2 [90]Oxidative burstMacrophages ↗[89]

Thermal regulationO2-/H2O2 [96]HypothermiaLow body temperature 30-33°C[91]

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