Review Article
The Naked Mole Rat: A Unique Example of Positive Oxidative Stress
Table 1
Potential positive effects of ROS in naked mole rats.
| | Type of ROS | Gene/mechanisms | Naked mole rat | Ref. |
| Cellular homeostasis | H2O2 [75] | Nrf2 | Fibroblasts: Nrf2 ↗ Liver: Nrf2 ↗ | [80–82] | H2O2 [77] | p53 | Fibroblasts: p53 ↗ Liver: p53 ↗ | [80, 83] | H2O2 [84] | PTEN | 17 copies of PTEN pseudogenes | [85] |
| Immune system | O2∙-/H2O2 [90] | Oxidative burst | Macrophages ↗ | [89] |
| Thermal regulation | O2∙-/H2O2 [96] | Hypothermia | Low body temperature 30-33°C | [91] |
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