Antiproliferative and Antitumour Effect of Nongenotoxic Silver Nanoparticles on Melanoma Models

Figure 2

Reactive oxygen species production in melanoma cells treated with of AgNPs or CisPt. Quantification of ROS production in B16-F10 cell cultures treated with the of AgNPs or CisPt was performed by flow cytometry and fluorescent markers. Total ROS was determined with DCFDA (purple lines) and mitochondrial superoxide with MitoSOX (black lines). indicates a statistically significant difference of comparing total ROS generation data with mitochondrial superoxide data.