Antiproliferative and Antitumour Effect of Nongenotoxic Silver Nanoparticles on Melanoma Models

Figure 6

Cytotoxic and genotoxic effects quantified on erythrocytes from circulating blood samples. (a) Average of micronucleated erythrocytes (MNE) scored in 10,000 of total erythrocytes, (b) polychromatic erythrocytes (PCE) in 1000 erythrocytes, and (c) representative images of scored polychromatic erythrocytes (polychromatic erythrocytes, red; normochromatic erythrocytes, green; micronuclei, yellow). Healthy mice (negative control), untreated mice (melanoma control), and mice with melanoma treated with CisPt, PVP, and the indicated doses of AgNPs. Red lines indicate the normal micronuclei range reported for C57BL/6J mice, polychromatic erythrocytes (red), normochromatic erythrocytes (green), micronuclei (yellow).

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