Antiproliferative and Antitumour Effect of Nongenotoxic Silver Nanoparticles on Melanoma Models

Table 1

Physicochemical properties of AgNPs employed on in vivo murine melanoma models.

Property	Lin et al. [47]	Kang et al. [48]	This work
AgNP size (nm)		2.3
Protective agent	PVP	PVP	PVP
potential (mV)		-0.28	-15
Metallic silver content (% wt)	ND	ND	1.2
Initial tumour diameter (mm)	4-6	NA	10
Used dose: metallic silver (mg/kg)	1.5	1, 5, and 10	3, 6, and 12
Days of administration in treatment	5	NA	21
Dosage frequency	24 h	NA^†	48 h
Days without treatment before sacrifice	8	NA^†	7

ND: not determined. NA: not applicable.