Research Article
Effects of the (Pro)renin Receptor on Cardiac Remodeling and Function in a Rat Alcoholic Cardiomyopathy Model via the PRR-ERK1/2-NOX4 Pathway
Figure 5
Effects of ERK kinase inhibitor (PD98059) and telmisartan on ERK1/2 phosphorylation and NOX4 and TGF-β protein expression in CFs. (a) and (e) Representative western blot analysis of ERK1/2 phosphorylation and NOX4 and TGF-β protein expression. (b)–(d) and (f)–(h) Quantification of protein expression level of p-ERK1/2/t-ERK1/2, TGF-β/GAPDH, and NOX4/GAPDH. versus the alcohol group, versus the alcohol+PD98059 group, and versus the PRR+Tel group, and versus the PRR group. Tel: telmisartan.
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