A Bioinformatic Approach for the Identification of Molecular Determinants of Resistance/Sensitivity to Cancer Thermotherapy

Table 1

Overrepresented WikiPathways of (a) DAMP/ICD and (b) thermoresistance-associated genes.

DAMP/ICD
WikiPathways	Gene symbol	Adj. value
Cytokines and inflammatory response	IFNG, TNF, IL10, CD4, IL1B, IL6, IL12B	1.29-13
Inflammatory response pathway	IFNG, CD80, IL2RA, CD86, TNFRSF1A	8.18-11
Toll-like receptor signaling pathway	TNF, CD80, IL1B, CD86, IL6, IL12B	3.01-10
Allograft rejection	IFNG, TNF, CD80, IL10, CD86, IL12B	3.01-10
Regulation of toll-like receptor signaling pathway	TNF, CD80, IL1B, CD86, IL6, IL12B	1.15-09
Selenium pathway	IFNG, TNF, IL1B, IL6, ICAM1	1.47-08
TCR signaling pathway	CD8A, CD4, IL1B, IL6	1.06-06
TNF alpha signaling pathway	TNF, HSP90AA1, IL6, TNFRSF1A	1.06-06
Th1-Th2	IL10, IL12B	1.49-05
SIDS susceptibility pathways	TNF, IL10, IL1B, IL6	1.49-05
Alzheimer’s disease	TNF, IL1B, TNFRSF1A	2.52-05
Type II interferon signaling (IFNG)	IFNG, IL1B, ICAM1	2.52-05
Senescence and autophagy	IFNG, IL1B, IL6	7.51-05
Monoamine transport	TNF, IL1B	0.0002
NOD pathway	HSP90AA1, IL1B	0.0003
AhR pathway	TNF, HSP90AA1	0.0003
TSLP signaling pathway	IL2RA, IL6	0.0004
TWEAK signaling pathway	TNF, IL6	0.0005
TGF beta signaling pathway	IFNG, TNF	0.0006
Thermoresistance
WikiPathways	Gene symbol	Adj. value
Parkin-ubiquitin proteasomal system pathway	HSPA4, HSPA1A, HSPA1B, HSPA4	7.81-05
Prostate cancer	JUN, PLK1, ABCC4, FOS, HSP90AB1	0.0001
FAS pathway and stress induction of HSP regulation	JUN, RB1, HSPB1	0.0005
MAPK signaling pathway	JUN, HSPB1, FOS, HSPA1A	0.0005
Integrated pancreatic cancer pathway	JUN, PLK1, EGR1, HSP90AB1	0.0006
TSH signaling pathway	JUN, RB1, FOS	0.0006
Androgen receptor signaling pathway	JUN, RB1, BAG1	0.0009
Oncostatin M signaling pathway	JUN, EGR1, FOS	0.0009
Drug induction of bile acid pathway	ABCC4, ABCB1	0.0009