AT1R-Mediated Apoptosis of Bone Marrow Mesenchymal Stem Cells Is Associated with mtROS Production and mtDNA Reduction

<div>Apoptosis of BMMSCs after treatment with 0, 100 nM, 1 <i>μ</i>M, and 10 <i>μ</i>M Ang II for 12 hours. (a) Poly Caspase and DAPI staining showing apoptosis of BMMSCs. (b) Quantification of the numbers of caspase-positive cells. (c) Quantification of the numbers of the cells with condensed and/or fragmented nuclei. (d and e) Western-blotting assay showing Bcl2 and Bax expressions in BMMSCs after exposure to different doses of Ang II. (f) The ratio of Bcl2/Bax. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: AT1R-Mediated Apoptosis of Bone Marrow Mesenchymal Stem Cells Is Associated with mtROS Production and mtDNA Reduction 