Oxidative Medicine and Cellular Longevity / 2019 / Article / Fig 3

Research Article

AT1R-Mediated Apoptosis of Bone Marrow Mesenchymal Stem Cells Is Associated with mtROS Production and mtDNA Reduction

Figure 3

Apoptosis of BMMSCs after treatment with 0, 100 nM, 1 μM, and 10 μM Ang II for 12 hours. (a) Poly Caspase and DAPI staining showing apoptosis of BMMSCs. (b) Quantification of the numbers of caspase-positive cells. (c) Quantification of the numbers of the cells with condensed and/or fragmented nuclei. (d and e) Western-blotting assay showing Bcl2 and Bax expressions in BMMSCs after exposure to different doses of Ang II. (f) The ratio of Bcl2/Bax. Bar graphs represent ( per group). vs. control.

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