AT1R-Mediated Apoptosis of Bone Marrow Mesenchymal Stem Cells Is Associated with mtROS Production and mtDNA Reduction

<div>AT1R blocker losartan suppresses Ang II-induced mtROS generation and mtDNA reduction in BMMSCs. (a) MitoSOX™ superoxide indicator staining showing mitochondrial ROS levels in BMMSCs after pretreatment with 10 <i>μ</i>M losartan followed by exposure to 10 <i>μ</i>M Ang II. (b) PicoGreen staining showing mitochondrial DNA levels in BMMSCs after pretreatment with losartan followed by exposure to 10 <i>μ</i>M Ang II. (c) Quantification of MitoSOX fluorescence density (AU). (d) Quantification of PicoGreen fluorescence density except nuclei (AU). 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: AT1R-Mediated Apoptosis of Bone Marrow Mesenchymal Stem Cells Is Associated with mtROS Production and mtDNA Reduction 