Resveratrol Enhances Apoptotic and Oxidant Effects of Paclitaxel through TRPM2 Channel Activation in DBTRG Glioblastoma Cells

Figure 1

Effect of resveratrol (RESV and 50 μM for 24 hours) and paclitaxel (PAX and 50 μM for 24 hours) incubations on the TRPM2 current densities (pA/pF) in the DBTRG cells ( and ). The TRPM2 currents in the cells were induced by intracellular ADPR (1 mM in patch pipette), but they were blocked by extracellular ACA (25 μM) in the patch-chamber. W.C.: whole cell. (a) Control (Ctr): original recordings from Ctr cell (without ADPR stimulation). (b) Ctr + ADPR group (with ADPR stimulation but not PAX and RESV treatments). (c) Ctr + ADPR + ACA group (with ADPR stimulation and PAX treatment but not RESV treatment). (d) PAX + ADPR group (with ADPR stimulation and PAX plus RESV treatments). (e) Current densities. ( versus control. versus control + ADPR group. versus control + ADPR + ACA group. versus PAX + ADPR group. versus PAX + ADPR + ACA group. versus PAX + RESV + ADPR group).

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