Resveratrol Enhances Apoptotic and Oxidant Effects of Paclitaxel through TRPM2 Channel Activation in DBTRG Glioblastoma Cells
Effect of resveratrol (RESV and 50 μM for 24 hours) and paclitaxel (PAX and 50 μM for 24 hours) incubations on the TRPM2 current densities (pA/pF) in the DBTRG cells ( and ). The TRPM2 currents in the cells were induced by intracellular ADPR (1 mM in patch pipette), but they were blocked by extracellular ACA (25 μM) in the patch-chamber. W.C.: whole cell. (a) Control (Ctr): original recordings from Ctr cell (without ADPR stimulation). (b) Ctr + ADPR group (with ADPR stimulation but not PAX and RESV treatments). (c) Ctr + ADPR + ACA group (with ADPR stimulation and PAX treatment but not RESV treatment). (d) PAX + ADPR group (with ADPR stimulation and PAX plus RESV treatments). (e) Current densities. ( versus control. versus control + ADPR group. versus control + ADPR + ACA group. versus PAX + ADPR group. versus PAX + ADPR + ACA group. versus PAX + RESV + ADPR group).
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