Resveratrol Enhances Apoptotic and Oxidant Effects of Paclitaxel through TRPM2 Channel Activation in DBTRG Glioblastoma Cells
Effect of resveratrol (RESV and 50 μM for 24 hours) and paclitaxel (PAX and 50 μM for 24 hours) incubations on the Ca2+ florescence intensity through TRPM2 activation in the DBTRG cells. The cells were stained with Fluo3 calcium dye, and the of fluorescence in 15 mm2 of cell as arbitrary unit are presented; independent experiments. The cells were extracellularly stimulated by cumene hydroperoxide (CPx and 1 mM), but they were extracellularly inhibited by ACA (0.025 mM). The samples were analyzed by a laser confocal microscope fitted with a 40x oil objective. ( versus control (Ctr) group. versus Ctr + CPx. versus Ctr + CPx + ACA group. versus RESV + PAX group. versus RESV + CPx and PAX + CPx groups. versus RESV + CPx + ACA and PAX + CPx + ACA groups. versus PAX + RESV group. versus PAX + RESV + CPx group).
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