Resveratrol Enhances Apoptotic and Oxidant Effects of Paclitaxel through TRPM2 Channel Activation in DBTRG Glioblastoma Cells

<div>Effect of resveratrol (RESV and 50 <i>μ</i>M for 24 hours) and paclitaxel (PAX and 50 <i>μ</i>M for 24 hours) treatments on (a) mitochondrial membrane depolarization (JC1), (b) intracellular DCFH-DA ROS production, (c) <i>o</i>- and <i>m</i>-tyrosine levels, and (d) BCR and UCR ratios in the DBTRG cells (<svg height="9.10327pt" id="M68" style="vertical-align:-0.3499298pt" version="1.1" viewbox="-0.0498162 -8.75334 58.1969 9.10327" width="58.1969pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M797 0V26C739 32 732 36 732 103V296C732 394 682 449 605 449C576 449 550 437 529 423C504 407 475 389 446 366C425 418 382 449 334 449C303 449 279 437 253 421C222 403 201 385 180 371V452C135 432 85 419 41 411V388C99 379 102 374 102 310V103C102 38 93 32 27 26V0H238V26C189 32 180 38 180 103V338C210 363 250 390 289 390C351 390 377 348 377 275V103C377 37 368 32 306 26V0H520V26C465 32 456 38 456 101V296C456 314 455 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Resveratrol Enhances Apoptotic and Oxidant Effects of Paclitaxel through TRPM2 Channel Activation in DBTRG Glioblastoma Cells 