Astragaloside IV Exerts a Myocardial Protective Effect against Cardiac Hypertrophy in Rats, Partially via Activating the Nrf2/HO-1 Signaling Pathway

Figure 8

Schematic diagram depicting the effects of ASIV on cardiac hypertrophy via activating the Nrf2/HO-1 signaling pathway in vivo and in vitro. Stimulation due to AAC surgery and Ang II-induced ROS production. ASIV intervention activated Nrf2 and promoted the expression of the downstream antioxidant gene HO-1, inhibiting the production of ROS and, thus, ameliorating oxidative stress and damage and, ultimately, cardiac hypertrophy.