Acid Stress Triggers Resistance to Acetic Acid-Induced Regulated Cell Death through Hog1 Activation Which Requires RTG2 in Yeast

Figure 5

A model for the AA-RCD adaptive pathway due to acid stress. Acid stress triggers resistance to AA-RCD through a pathway in which RTG2 does not activate the CIT2 upregulation, i.e., mitochondrial retrograde response, but it is required for Hog1 activation which controls the transcriptional upregulation of CTT1, encoding cytosolic catalase. The concomitant increase of catalase activity inhibits the ROS-dependent pathway causing AA-RCD.