tert-Butylhydroquinone Treatment Alleviates Contrast-Induced Nephropathy in Rats by Activating the Nrf2/Sirt3/SOD2 Signaling Pathway
Activation of the Nrf2/Sirt3/SOD2 signaling pathway was essential to the antioxidative effects of t-BHQ in CIN-induced oxidative injury in HK-2 cells. (a) western blot of Sirt3, Ac-SOD2, and SOD2. (b) Quantitative analysis of Sirt3. (c) Quantitative analysis of Ac-SOD2. (d) Quantitative analysis of SOD2. HK-2 cells were infected by si-Nrf2 and then treated with 50 mg/ml ioversol for 24 h to induce oxidative stress. Data were expressed as . versus the si-control group; & versus the si-control+ioversol group; # versus the si-control+ioversol+t-BHQ group.