tert-Butylhydroquinone Treatment Alleviates Contrast-Induced Nephropathy in Rats by Activating the Nrf2/Sirt3/SOD2 Signaling Pathway
Immunohistochemical staining and semiquantitative analysis of Nrf2 and Sirt3 in the kidneys of different groups. (a) Immunohistochemical staining of Nrf2 and Sirt3. (b) Quantitative analysis of Nrf2. (c) Quantitative analysis of Sirt3. Original magnification ×200. Rats in the ioversol group were sequentially injected in the tail vein: indomethacin (10 mg/kg), followed by L-NAME (100 mg/kg) and ioversol (2.9 g/kg) 15 and 30 min later. t-BHQ was administered to rats in the t-BHQ+ioversol group. Data were expressed as the . versus the control group; & versus the ioversol group.