Maggot Extracts Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis via the Activation of Nrf2

Figure 6

The maggot extracts regulate the proinflammatory cytokines and Nrf2 in the colon of mice with DSS-induced colitis. Mice were treated as explained in Figure 2. mRNA expression levels of the proinflammatory genes including TNF-α (a), IL-6 (b), and IL-1β (c) as well as oxidative stress-related proteins including Nrf2 (d), p22-phox (e), and Ho-1 (f) in colonic tissues were determined by real-time PCR. The housekeeping gene GAPDH was used as a loading control. Data are expressed as the . , , and ; ns = no significance.

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