Effect of Hypoxia-Induced MicroRNA-210 Expression on Cardiovascular Disease and the Underlying Mechanism

Table 1

Genes regulated by miR-210 in the CVD model.

Target	Function	Cell line	References
APC	Antiproliferation, proapoptosis, and cell cycle inhibition	CM, HCtASMC, and HCAEC	[21, 41]
BNIP3	Proapoptosis	H9C2	[16]
CASP8AP2	Proapoptosis	HUVEC	[42]
Ctgf	Antiangiogenesis, profibrosis	HL-1, cardiac fibroblast	[43, 44]
Dapk1	Cell cycle inhibition, proapoptosis, and antimigration	HL-1	[43]
E2F3	Cell cycle inhibition, proapoptosis	hPASMC, CM	[45, 46]
EFNA3	Antiangiogenesis, proapoptosis	CT, HL-1, and HUVEC	[34, 43, 47]
HGF	Proangiogenesis, proproliferation, promigration, and prodifferentiation	HUVEC	[39]
HOXA9	Antiproliferation	CT	[34]
ISCU	Mitochondrial metabolism progression	H9C2, hPASMC, and hPAEC	[7, 14, 17, 48]
MKP1	Antiproliferation	hPASMC	[49]
PDK1	Proapoptosis	HAEC	[15]
Ptp1b	Antiangiogenesis, proapoptosis	HL-1	[43]
ROD1	Antidifferentiation (seedless)	HUVEC	[50]
RUNX3	Antiproliferation, antimigration	HUVEC	[51]
SPRED2	Antimigration	HASMC, HUVEC	[52]
VEGF	Proangiogenesis, promigration, and proinvasion	HUVEC	[21, 37, 38, 47, 51]