Effect of Hypoxia-Induced MicroRNA-210 Expression on Cardiovascular Disease and the Underlying Mechanism

Table 2

Protection mechanism of microRNA-210 in hypoxic cells.

Function	Gene	Reference
Antiapoptosis	APC/BNIP3/CASP8AP2/Dapk1/E2F3/EFNA3/PDK1/Ptp1b	[15, 16, 21, 34, 41–43, 45, 46]
Proangiogenesis	Ctgf/HGF/Ptp1b/VEGF	[37–39, 43, 47, 51]
Proproliferation	APC/HGF/ HOXA9/MKP1/RUNX3	[21, 34, 39, 41, 49, 51]
Promigration	Dapk1/HGF/KCMF1/RUNX3/SPRED2/VEGF	[21, 37–39, 43, 47, 51–53]
Prodifferentiation	HGF/ROD1	[39, 50]
Cell cycle progression	APC/Dapk1/E2F3/EFNA3	[21, 34, 39, 41, 43, 45–47]
Antifibrosis	Ctgf	[43, 44]
Mitochondrial metabolism inhibition	ISCU	[7, 14, 48]
Others	HSD17B1	[70]