Propofol Alleviates Apoptosis Induced by Chronic High Glucose Exposure via Regulation of HIF-1α in H9c2 Cells
The effects of propofol on the expression of apoptosis-related proteins in H9c2 cells during high glucose stress. The levels of Bcl-2, cleaved caspase-3, and P53 were determined by western blotting, and GAPDH was used as positive control. (a) The effects of propofol on Bcl-2 expression. (b) The effects of propofol on cleaved caspase-3 expression. (c) The effects of propofol on P53 expression. Data were shown as from five independent experiments. ,, and versus control; #,##, and ### versus the high glucose-treated group without drugs. Ctrl = blank control group; 0 = high glucose model group; P5 = 5 μM propofol pretreatment group; P10 = 10 μM propofol pretreatment group; P20 = 20 μM propofol pretreatment group; and HG = 22 mM high glucose culture.
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