Propofol Alleviates Apoptosis Induced by Chronic High Glucose Exposure via Regulation of HIF-1α in H9c2 Cells
The effects of propofol on the levels of SIRT3, SOD2, PHD2, and HIF-1α in H9c2 cells during high glucose stress. The levels of SIRT3, SOD2, PHD2, and HIF-1α were determined by western blotting, and GAPDH was used as positive control. The quantification of the effects of propofol on protein levels of SIRT3 (a), SOD2 (b), PHD (c), and HIF-1α (d). Data were shown as from five independent experiments. ,, and versus control; #,##, and ### versus the high glucose-treated group without drugs. Ctrl = blank control group; 0 = high glucose model group; P5 = 5 μM propofol pretreatment group; P10 = 10 μM propofol pretreatment group; P20 = 20 μM propofol pretreatment group; and HG = 22 mM high glucose culture.
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