CD28 Deficiency Ameliorates Blast Exposure-Induced Lung Inflammation, Oxidative Stress, Apoptosis, and T Cell Accumulation in the Lungs via the PI3K/Akt/FoxO1 Signaling Pathway
CD28 deficiency attenuates blast exposure-induced acute lung injury. (a, b) Representative western blot images and quantitative analysis of CD28 and β-actin. Fold changes in WT (green bar) and CD28-/- (red bar) expressions are shown. (c, d) Lung weight/body weight and the ratio of wet weight to dry weight in each group. (e) Representative histopathological images of each group (HE staining, ). All experiments were repeated at least three times. Results are expressed as the ( per group). versus the control group; versus the WT group (two-way ANOVA; Bonferroni post hoc test). WT: C57BL/6 wild-type mice; CD28-/-: CD28 knockout mice.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.