CD28 Deficiency Ameliorates Blast Exposure-Induced Lung Inflammation, Oxidative Stress, Apoptosis, and T Cell Accumulation in the Lungs via the PI3K/Akt/FoxO1 Signaling Pathway

Figure 5

CD28 deficiency inhibits CD3⁺ T cell accumulation in blast exposure-induced lung tissues. At 24 h and 48 h postblast, flow cytometry data were collected from C57BL/6 WT and CD28^-/- mice. (a, b) Flow cytometry plots and quantitative data represent the percentage of CD3⁺ T cells in lungs. (c) Quantitative data represent the total numbers of CD3⁺ T cells and CD3⁺ CD28⁺ T cells in lungs after blast injury. All experiments were repeated at least three times. Results are expressed as the ( per group). versus the control group; versus the WT group (two-way ANOVA; Bonferroni post hoc test). WT: C57BL/6 wild-type mice; CD28^-/-: CD28 knockout mice.

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