FGF21 Mediates Mesenchymal Stem Cell Senescence via Regulation of Mitochondrial Dynamics

<div>Silencing FGF21 induces MSC senescence via ROS generation. (a) Representative images of Mito-Sox staining in BM-MSCs at P4, P8, and P12 (i). Quantitative analysis of ROS generation in BM-MSCs at P4, P8, and P12 (ii). (b) Representative images of Mito-Sox staining in BM-MSCs at P4 from the control siRNA or FGF21 siRNA or FGF21 siRNA+MitoTEMPO-treated group (i). Quantitative analysis of ROS generation in control siRNA or FGF21 siRNA or FGF21 siRNA+MitoTEMPO-treated BM-MSCs at P4 (ii). (c) Representative images of SA-<i>β</i>-gal staining in BM-MSCs at P4 from the control siRNA or FGF21 siRNA or FGF21 siRNA+MitoTEMPO-treated group (i). Percentage of SA-<i>β</i>-gal-positive senescent cells in control siRNA or FGF21 siRNA or FGF21 siRNA+MitoTEMPO-treated BM-MSCs at P4 (ii). 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: FGF21 Mediates Mesenchymal Stem Cell Senescence via Regulation of Mitochondrial Dynamics 