High Levels of <i>β</i>-Amyloid, Tau, and Phospho-Tau in Red Blood Cells as Biomarkers of Neuropathology in Senescence-Accelerated Mouse

<div>Quantitative assay of <i>α</i>-syn and misfolded protein’s heterocomplex in both RBCs and in brain tissues. Levels of <i>α</i>-syn, <i>α</i>-syn-A<i>β</i>, and <i>α</i>-syn-tau in brain tissues (a, c, and e) and in RBCs (b, d, and f) from SAMP8 and SAMR1 mice at 6 and 8 months were assessed by specific immunoenzymatic assays. Difference among groups were evaluated by one-way ANOVA. <svg height="8.68572pt" id="M96" style="vertical-align:-0.0498209pt" version="1.1" viewbox="-0.0498162 -8.6359 8.15071 8.68572" width="8.15071pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g></svg> values were adjusted with Sidak’s multiple comparison test: <span class="nowrap"><svg height="10.7395pt" id="M97" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 50.9184 10.7395" width="50.9184pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g 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d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> between the indicated subgroups.</div>

Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: High Levels of <i>β</i>-Amyloid, Tau, and Phospho-Tau in Red Blood Cells as Biomarkers of Neuropathology in Senescence-Accelerated Mouse 

Oxidative Medicine and Cellular Longevity

High Levels of β-Amyloid, Tau, and Phospho-Tau in Red Blood Cells as Biomarkers of Neuropathology in Senescence-Accelerated Mouse

Figure 7