High Levels of β-Amyloid, Tau, and Phospho-Tau in Red Blood Cells as Biomarkers of Neuropathology in Senescence-Accelerated Mouse

Table 1

Concentrations of Aβ, α-syn, tau, p-tau, α-syn-Aβ, and α-syn-tau in brain tissues and RBCs of SAMP8 and SAMR1 at different ages.

Brain	Aβ (ng/μg)	α-Syn (ng/μg)	Tau (ng/μg)	p-Tau (pg/μg)	α-Syn-Aβ (ng/μg)	α-Syn-tau (ng/μg)
SAMR1 6 m
SAMP8 6 m
SAMR1 8 m			^#
SAMP8 8 m		^##	^##		^#	^###
RBCs	Aβ (ng/mg)	α-Syn (ng/mg)	Tau (ng/mg)	p-Tau (ng/mg)	α-Syn-Aβ (ng/mg)	α-Syn-tau (ng/mg)
SAMR1 6 m
SAMP8 6 m
SAMR1 8 m				^##	^#
SAMP8 8 m	^#		^#	^##	^#	^##

Values are expressed as . Differences among the groups were evaluated by a nonparametric analysis (Kruskal-Wallis). , , and indicate significant differences of SAMR1 versus the age-matched SAMP8. ^#, ^##, and ^### indicate significant differences between SAMR1 6 m and SAMR1 8 m or between SAMP8 6 m and SAMP8 8 m.