[Retracted] Apatinib Promotes Apoptosis of Pancreatic Cancer Cells through Downregulation of Hypoxia-Inducible Factor-1α and Increased Levels of Reactive Oxygen Species

Figure 6

Apatinib inhibited the expression of HIF-1α and the AKT/mTOR pathway. (a) CFPAC-1 and SW1990 cells were treated with apatinib (0 or 16 μM) for 24 h, and alterations in the expression of HIF-1α and VEGF were determined through western blotting. GAPDH was included as a loading control. (b) CFPAC-1 and SW1990 cells were treated with different concentrations of apatinib (0, 8, and 16 μM) for 24 h, and the levels of phosphorylated AKT, mTOR, and LC3 were determined through western blotting. GAPDH was used as a loading control. All experiments were performed in triplicate.

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